BPE 2009 BIOPROCESSING EQUIPMENT PDF

Buy ASME BPE: BIOPROCESSING EQUIPMENT from SAI Global. The next edition of this Standard is scheduled for publication in This Standard represents the work of the BPE Standards Committee and includes the follow- ASME BIOPROCESSING EQUIPMENT COMMITTEE. ASME BPE Supplement. Supplement to Bioprocessing Equipment. Amendment by ASME International, 05/19/ This document is an amendment.

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The yel-low control document travels with the part as it is fabricated. OE Group 6 group. I Inspector Delegates t D l t 4 levels of qualification: Limits on inside diameter ID and outside diameter OD concavity and misalignment are set to promote drainability and cleanability of weld surfaces.

The BPE Standard deals with the requirements of the bioprocessing and pharmaceutical industries, as well as other applications with relatively high levels of hygienic requirements or bioburden control.

Weld discoloration was shown to increase with increasing amounts of oxygen added to the ID argon purge.

ASME BPE – Wikipedia

Installation practices at modern biopharmaceutical, pharmaceutical and some food and dairy plants today are quite different than those at similar construction sites 20 years ago. Installation of equipment in biopharmaceutical applications have been made more efficient by the use of skid-mounted equipment modules so that installation and fabrication can be telescoped into a shorter timescale.

Welding documentation includes docu-ments certifying the welding procedures and welding personnel to ASME Sect. New resource material will be provided on electropolishing, passivation, elastomer performance, metallic materials of construction, polymer surface finishes, corrosion testing and stainless steel rouge.

Welds at that time were often discolored due to poor inert gas purging. Unpenetrated welds are entrapment sites for product and are difficult to clean. Reasons for greater percent of orbital welds In the past there were many places in systems and equipment that an orbital weld head would not fit so a larger percentage of welds had to be done man-ually.

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This assures that procedures are consistenly carried out and increases the likelyhood that all welds will be of similar high quality.

Improvements in Installation Practices of Bioprocess Piping Systems

The MJSC developed a set of weld criteria that, in addition to code criteria for adequate structural integrity, was designed to minimize the growth of microorganisms and promote cleanability. Achieving welds of consistent high quality compatible with the principles of hygienic design was an initial goal of the BPE Committee, but the Standard is by no means limited to welding and fabrication issues.

Passivation restores, at least in part elements in the passive surface layer that are disturbed by welding and the concomitant loss of corrosion resistance. The BPE Surface Finish Subcommit-tee has added a new non-mandatory appendix to the Edition of BPE that offers guidelines to owners for qualification of their passivation proce-dures.

All welds must have complete penetration to the inside surface of the weld which, in bioprocess applications, is usually the product contact surface. The BPE has also been expanded to include new sections on process instrumentation, hygienic pumps, hygienic hose assemblies and rotary spray devices. Fabrication and in some cases installation and commissioning of the skids can occur at the same time as plant construction. Photo cour-tesy of Arc Machines, Inc. Other dimensions affect fit-up, etc.

ASME BPE 2009 B P E

While no color is per-mitted on the weld itself, a slight color may be allowed on the HAZ. Speak up and be an active participant in the Subcommittee Sessions.

New Nominal one inch fitting design. Since existing standards were insufficient for this new technology, the engineer recruited a group of suppliers and end users in the industry and they approached the American Society of Mechanical Engineers ASME for permission to begin the writing of a new standard for equipkent developing Bioprocess Industry. Metallic Materials of Construction? Test coupons or sample welds are made and evaluated nioprocessing to production welding to demonstrate that the welding equipment is working properly and that the purge is satisfactory Figure 5.

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New Supplier Certification Program! Not too restrictive or expensive? Revisions appeared in, and Determine where your technical strengths would bioprocewsing. Weld discoloration relative to amounts of oxygen added to ID purge gas.

This presentation will summarize the new BPE resources and requirements for the design and delivery of components and process systems for use in bioprocessing, pharmaceutical, and personal care product industries. The BPE Committee has reached its initial goal of achieving welds of consistent high quality compatible with the princi-ples of hygienic design. But a greater problem equiment when welding fittings to tubing with large differences in the sulfur content.

Orbital welding has been central to this advancement while standardiza-tion of weld end dimensions and chemistry by the BPE have resulted in more repeatable welding procedures. The BPE Standard is a consensus standard with work done by volunteers.

In the past there were many places in systems and equipment that an orbital weld head would not fit so a larger percentage of welds had to be done man-ually. This publication will include new content on the design of process systems such as bioreactors, fermentors, autoclaves, process gasses, CIP distribution and single-use equipment.

Color chart from AWS D Photo courtesy of Kenyon Engineering. A good machined end-preparation is important for fit-up of the weld joint and for achieving repeatable orbital welds.

ASME BPE 修改说明介绍_图文_百度文库

It has helped to consolidate acceptable practices including procedures for examination, inspection and documentation of welds in bioprocess piping sys-tems. Examination is done by the installer or the person performing the weld while inspection must be done by the owner or his representative which may be a third 20099 QC company or consultant.

Guidelines for Cleaning Vessels? While the AISI specified only an upper limit for sulfur of 0.